Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI: An observational comparative study

Ole De Backer*, Hanna Ratcovich, Luigi Biasco, Frants Pedersen, Steffen Helqvist, Kari Saunamaki, Hans Henrik Tilsted, Peter Clemmensen, Goran Olivecrona, Henning Kelbaek, Erik Jørgensen, Thomas Engstrøm, Lene Holmvang

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

The newer oral P2Y12 inhibitors prasugrel and ticagrelor have been reported to be more potent and faster-acting antiplatelet agents than clopidogrel. This study aimed to investigate whether prehospital loading with prasugrel or ticagrelor improves early coronary reperfusion as compared to prehospital loading with clopidogrel in a real-world STelevation myocardial infarction (STEMI) setting. Over a 70-month period, 3497 patients with on-going STEMI of less than 6 hours and without cardiac arrest or cardiogenic shock underwent primary percutaneous coronary intervention (PPCI) at our centre. The primary endpoint of this study was the proportion of patients who did not meet the criteria for TIMI (Thrombolysis In Myocardial Infarction) flow grade 3 in the infarct-related artery at initial angiography before PPCI. Prehospital loading with prasugrel (n = 883) or ticagrelor (n = 491) did not significantly improve coronary reperfusion as compared to prehospital loading with clopidogrel (n = 1,532) – a TIMI-flow 3 at initial angiography was absent in 71.7 %, 69.0 % and 71.5 % of patients, respectively. Major adverse cardiac event (MACE) rates were low at 30 days (3.4 % to 4.0 %) and did not significantly differ between the different P2Y12 inhibitor regimens. In conclusion, this large observational, non-randomised study is the first to show that prehospital loading with the newer P2Y12 inhibitors does not improve early coronary reperfusion as compared to prehospital loading with clopidogrel in a PPCI cohort excluding cardiac arrest and cardiogenic shock.

OriginalsprogEngelsk
Sider (fra-til)623-631
Antal sider9
TidsskriftThrombosis and Haemostasis
Vol/bind114
Udgave nummer3
DOI
StatusUdgivet - 1 jan. 2015
Udgivet eksterntJa

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