TY - JOUR
T1 - Pregnancy-associated plasma protein A in non-cardiac conditions
AU - Iversen, Kasper Karmark
AU - Teisner, Ane Sogaard
AU - Teisner, Borge
AU - Kliem, Anette
AU - Bay, Morten
AU - Kirk, Vibeke
AU - Nielsen, Henrik
AU - Boesgaard, Soren
AU - Grande, Peer
AU - Clemmensen, Peter
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Objective: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease. Design and methods: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes. Results: PAPP-A was detectable (≥ 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p = 0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A. Conclusion: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.
AB - Objective: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease. Design and methods: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes. Results: PAPP-A was detectable (≥ 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p = 0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A. Conclusion: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.
KW - Coronary artery disease
KW - Non-cardiac conditions
KW - Pregnancy-associated plasma protein A
KW - Specificity
UR - http://www.scopus.com/inward/record.url?scp=41849101012&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2008.01.012
DO - 10.1016/j.clinbiochem.2008.01.012
M3 - Article
C2 - 18279673
AN - SCOPUS:41849101012
SN - 0009-9120
VL - 41
SP - 548
EP - 553
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 7-8
ER -