Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome

Kasper K. Iversen, Ane S. Teisner, Borge Teisner, Anette Kliem, Pia Thanning, Henrik Nielsen, Peter Clemmensen, Peer Grande

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Objectives: To describe the presence and time-related pattern of circulating pregnancy associated plasma protein A (PAPP-A) levels in patients with non ST-segment elevation acute coronary syndrome (NSTE-ACS). Design and methods: Consecutively admitted patients (N = 573) with clinical signs of NSTE-ACS were included. Blood samples for analysis of PAPP-A were drawn at admission and every 6-8 h until levels of biomarkers of myocardial necrosis showed a consistent decrease. Results: High-risk NSTE-ACS was diagnosed in 123 patients (23%). Significantly more patients with high-risk NSTE-ACS (63%) had detectable PAPP-A than did those with low-risk NSTE-ACS (49%) (P < 0.001). PAPP-A concentrations were significantly associated with typical angina at admission, significant ST-depressions on the ECG, multivessel disease and presence of high-risk NSTE-ACS. Conclusion: PAPP-A seems to be a marker ischaemia both in patients with low- and high-risk NSTE-ACS, possibly due to the release of PAPP-A from the vulnerable plaque.

    OriginalsprogEngelsk
    Sider (fra-til)828-834
    Antal sider7
    TidsskriftClinical Biochemistry
    Vol/bind42
    Udgave nummer9
    DOI
    StatusUdgivet - 1 jun. 2009

    Fingeraftryk Udforsk hvilke forskningsemner 'Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome' indeholder.

    Citationsformater