Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome

Kasper K. Iversen, Morten Dalsgaard, Ane S. Teisner, Mikkel Schoos, Borge Teisner, Henrik Nielsen, Peer Grande, Peter Clemmensen

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Objectives: To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction. Design and methods: Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction. Results: Median age of patients included (415) was 67. years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7, p< 0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4, p= 0.01). Conclusion: In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction.

    OriginalsprogEngelsk
    Sider (fra-til)851-857
    Antal sider7
    TidsskriftClinical Biochemistry
    Vol/bind43
    Udgave nummer10-11
    DOI
    StatusUdgivet - 1 jul. 2010

    Fingeraftryk Udforsk hvilke forskningsemner 'Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome' indeholder.

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