Prednisolonbehandling af respiratorisk syncytial virusinfektion: En randomiseret, kontrolleret undersogelse af 147 born

Susanne L.M. Bülow, Maria Nir, Eline Foged Levin, Birgitte Friis, Lise Lykke Thomsen, Jens Erik Klint Nielsen, Jens Christian Holm, Tina Møller Pedersen, Mie Birgitte Bonde-Hansen, Hans Erik Nielsen

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    Abstrakt

    Objects: Our objective was to evaluate the effect of systemic prednisolone as an adjunct to conventional treatment with β2-agonist, fluid replacement and respiratory support in hospitalized infants younger than 24 months with respiratory syncytial virus (RSV) infection. Methods: The study was randomized, double-blind and placebo-controlled. During the winter of 1995-96, 147 infants less than two years of age hospitalized with RSV infection were allocated to treatment with either systemic prednisolone mixture 2 mg/kg daily or placebo for 5 days. Results: Our main outcome measures were: 1. Acute effect variables: duration of stay in hospital, use of medicine and supportive measures while in hospital. 2. At follow-up one month after discharge: duration of illness, start in day care center, morbidity and use of medicine. 3. At follow-up one year after discharge: morbidity, use of medicine and skin prick tests with allergens. Conclusion: Prednisolone treatment had no effect on any of the outcome measures. We find our results in agreement with the largest studies reported earlier; therefore, corticosteroid, whether by systemic route or by inhalation, should not be prescribed to infants with RSV infection.

    Bidragets oversatte titelPrednisolone treatment of respiratory syncytial virus infection: A randomized controlled trial of 147 infants
    OriginalsprogDansk
    Sider (fra-til)6404-6408
    Antal sider5
    TidsskriftUgeskrift for laeger
    Vol/bind162
    Udgave nummer47
    StatusUdgivet - 20 nov. 2000

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