Postprandial lipemia after meals containing palm oil-interaction with carbohydrate metabolism

There is increasing evidence that postprandial lipemia may be of importance in development of atherosclerosis. As insulin plays a central role in lipid clearance it can be hypothesised that type and amount of carbohydrate will affect postprandial lipemia. Interactions between the carbohydrate metabolism and postprandial lipemia were investigated in 10 healthy young males in a randomised cross-over study. On two occations separated with a minimum of 3 weeks each subject consumed test meals (breakfast and lunch) containing 70 g (15 g and 55 g) of palm oil (40% of energy from fat). A 50 g glucose drink was taken at one of the occations together with the breakfast. One fasting and 15 postprandial blood samples were taken over 9 h. Glucose peak concentration was higher the glucose breakfast day than the day with no glucose (7.71 mmol/L (SD 0.84) vs. 6.36 mmol/L (SD 0.95), p=0-006). Total plasma triacyl-glycerol (TAG) peak concentration was higher the glucose breakfast day (2.54 mmol/L (SD 0.89) vs. 2.01 mmol/L (SD 0.88), p=0.04). mainly due to a higher (and later) chylomicron TAG peak concentration, p=0.01). VLDL and LDL TAG concentrations showed no differences, while HDL peak TAG concentration was higher the glucose breakfast day. p=0.05. In conclusion, glucose added to a palm oil containing diet increased postprandial lipemia, and results suggest a second meal effect of the macronutrient content of the previous meal. Similar studies with rapeseed and sunflower oil did not affect postprandial lipemia. Further analysis of insulin. CETP and LPL activity will be performed.