Positive predictive values of hematological procedure codes in the Danish National Patient Registry - a population-based validation study

Tine Bichel Lauritsen*, Jan Maxwell Nørgaard, Mathilde Egelund Christensen, Susanne Oksbjerg Dalton, Lene Sofie Granfeldt Østgård

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

BACKGROUND: The Danish National Patient Registry holds data on hematological procedure codes including date and type of treatment from all hematological departments in Denmark. The validity of the hematological procedure codes remains to be clarified before they are used in epidemiological research.

PATIENTS AND METHODS: Using the Danish Myelodysplastic Syndromes Database, we identified 897 patients diagnosed with myelodysplastic syndromes or chronic myelomonocytic leukemia treated at five Danish Hospitals between 1 January 2012 and 30 April 2019. From the Danish National Patient Registry, we ascertained information about hematological procedure codes and date of procedure registered on each patient and generated random samples. Using medical record review as the reference standard, we validated procedure codes in the Danish National Patient Registry and calculated positive predictive values (PPVs) with 95% confidence intervals (CIs) for each procedure code.

RESULTS: A total of 523 medical records (99% of the total sample) were available for review. PPVs for specific procedure codes ranged from 71% to 100%. The overall PPV was 91% (95% CI: 88%-92%), reflecting PPVs of 95% (95% CI: 92%-97%) for low-dose-chemotherapy, 90% (95% CI: 81%-96%) for high-dose chemotherapy, 99% (95% CI: 93%-100%) for allogeneic stem cell transplantation, 75% (95% CI: 62%-85%) for immuno-modulating agents, 80% (95% CI: 74%-85%) for growth factors, and 99% (95% CI: 99%-100%) for bone marrow examination. The accuracy of coding was consistent across geographic regions and year of registration/coding.

CONCLUSIONS: Hematological procedure codes reported to the Danish National Patient Registry had high PPVs and are suitable for epidemiological research.

OriginalsprogEngelsk
Sider (fra-til)963-971
Antal sider9
TidsskriftPharmacoepidemiology and Drug Safety
Vol/bind31
Udgave nummer9
Tidlig onlinedato31 maj 2022
DOI
StatusUdgivet - sep. 2022

Bibliografisk note

This article is protected by copyright. All rights reserved.

© 2022 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.

© 2022 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.

Fingeraftryk

Udforsk hvilke forskningsemner 'Positive predictive values of hematological procedure codes in the Danish National Patient Registry - a population-based validation study' indeholder.

Citationsformater