Plasma glucose reference interval in a low-risk population. 2. Impact of the new WHO and ADA recommendations on the diagnosis of diabetes mellitus

L. G.M. Jørgensen, M. Stahl, I. Brandslund, P. Hyltoft Petersen, K. Borch-Johnsen, F. De Fine Olivarius

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    The aim of the study was to establish a reference interval of fasting venous plasma glucose (FPG) from healthy individuals. A prospective modified cross-sectional population-based study was made with random selection of 2100 persons in age-stratified groups ≥18 years identified from the local Personal Identification Register. The invitation was accepted by 755 persons, of which 726 aged 18-92 years were eligible. They did not have a diabetes diagnosis, were non-pregnant and capable of fasting for 8 h. All participants filled in a questionnaire on medical risk factors. Blood for the FPG and haemoglobin A1c (HbA1c) measurements was drawn in accordance with a standardized procedure. A total of 302 participants carried diabetes risk indicators and were ruled out. The FPG concentrations in the remaining low-risk population (n=424) was 1n Gaussian distributed. The FPG 97.50 centile in this group was 6.4mmol/L (95% CI: 6.3-6.5 mmol/L), in contrast to the WHO and ADA theoretical limit of 6.1 mmol/L. Their diagnostic decision limit of 7.0 mmol/L FPG corresponded to the 99.86 centile of the FPG reference distribution (95% CI: 6.8-7.1). Subclassification of the reference population showed increasing FPG with increasing BMI and age and was higher in men than in women. The study determined the FPG 95% interfractile reference interval in a healthy population. The interval in glucose concentration between the 97.5 centile of the reference interval and the ADA-WHO diagnostic limit is very narrow. The clinical application of the diagnostic discriminator and the interpretation of the WHO-ADA grey zone from 6.1 to 7.0 mmol/L FPG may consequently be biased because of poorly defined limits and influence from BMI, age and gender.

    OriginalsprogEngelsk
    Sider (fra-til)181-190
    Antal sider10
    TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
    Vol/bind61
    Udgave nummer3
    DOI
    StatusUdgivet - 20 maj 2001

    Fingeraftryk Udforsk hvilke forskningsemner 'Plasma glucose reference interval in a low-risk population. 2. Impact of the new WHO and ADA recommendations on the diagnosis of diabetes mellitus' indeholder.

    Citationsformater