Placental Growth during Normal Pregnancy - A Magnetic Resonance Imaging Study

Lasse Langhoff, Lene Grønbeck, Sebastian Von Huth, Anna Axelsson, Connie Jørgensen, Carsten Thomsen, Niels Vejlstrup

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Abstrakt

Objective: To investigate normal human placental growth longitudinally throughout the second and third trimesters using MRI. Methods: Twenty normal, first-time singleton pregnancies were scanned 7 times between the 14th and 38th week of gestation, at 4-week intervals, using MRI. Placental volumes were measured in both sagittal and transversal slices. All placentas were weighed after delivery to make a comparative study. Results: Sixteen of the 20 women had increasing placental volumes from the 14th to 38th week of gestation. The 6th and 7th scan showed that 4 women had placentas of the same size. The mean placental volume increases linearly from the 14th till the 38th week of gestation, with a constant mean growth rate of 29.97 ml/week. The median placental volume extrapolated to delivery was to 856 ml (range 602-1,050 ml). The median weight of the exsanguinated placenta after delivery was 640 g (range 500-787 g). All pregnancies were carried to term, resulting in the delivery of healthy infants with good correlation between placental size and birth weight (R = 0.56, p = 0.009). Conclusion: Placental growth was measured systematically in a longitudinal study through the second and third trimesters using MRI. MRI provides a safe and feasible method to measure placental growth. The mean placental growth was linear throughout the second and third trimesters.

OriginalsprogEngelsk
Sider (fra-til)462-467
Antal sider6
TidsskriftGynecologic and Obstetric Investigation
Vol/bind82
Udgave nummer5
DOI
StatusUdgivet - 1 sep. 2017
Udgivet eksterntJa

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