TY - JOUR
T1 - Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model
T2 - A systematic review
AU - Ekeløf, Sarah
AU - Rosenberg, Jacob
AU - Jensen, Jan Skov
AU - Gögenur, Ismail
PY - 2014/8
Y1 - 2014/8
N2 - Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
AB - Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
KW - Acute myocardial infarction
KW - Experimental model
KW - Ischemia-reperfusion injury
KW - Pharmacology
UR - https://www.scopus.com/pages/publications/84906790793
U2 - 10.1007/s12265-014-9574-4
DO - 10.1007/s12265-014-9574-4
M3 - Review
C2 - 25004991
AN - SCOPUS:84906790793
SN - 1937-5387
VL - 7
SP - 570
EP - 580
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 6
ER -