Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: A systematic review

Sarah Ekeløf*, Jacob Rosenberg, Jan Skov Jensen, Ismail Gögenur

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

    OriginalsprogEngelsk
    Sider (fra-til)570-580
    Antal sider11
    TidsskriftJournal of Cardiovascular Translational Research
    Vol/bind7
    Udgave nummer6
    DOI
    StatusUdgivet - aug. 2014

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: A systematic review' indeholder.

    Citationsformater