Pesticide exposure in farming and forestry and the risk of uveal melanoma

Thomas Behrens, Elsebeth Lynge, Ian Cree, Jean Michel Lutz, Mikael Eriksson, Pascal Guénel, Franco Merletti, Maria Morales-Suarez-Varela, Noemia Afonso, Aivars Stengrevics, Joëlle Févotte, Svend Sabroe, Agustin Llopis-González, Giuseppe Gorini, Lennart Hardell, Andreas Stang, Wolfgang Ahrens

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    Abstrakt

    Purpose: Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries. Methods: Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression analyses and adjusted for several potential confounders. Results: 293 case and 3,198 control subjects were interviewed. We did not identify positive associations with activities in farming or forestry, pesticide application or pesticide mixing. No consistent positive associations were seen with exposure intensity level scores either. The only statistically significantly raised association in this study was for exposure to chemical fertilizers in forestry (OR = 8.93; 95% CI 1.73-42.13), but this observation was based on only six exposed subjects. Results did not change when we restricted analyses to morphologically verified cases and excluded proxy interviews as well as cancer controls. We did not observe effect modification by sex or eye color. Conclusions: Risk estimates for pesticide exposures and occupational activities in agriculture and forestry were not increased and did not indicate a hormonal mechanism due to these exposures.

    OriginalsprogEngelsk
    Sider (fra-til)141-151
    Antal sider11
    TidsskriftCancer Causes and Control
    Vol/bind23
    Udgave nummer1
    DOI
    StatusUdgivet - 1 jan. 2012

    Fingeraftryk Udforsk hvilke forskningsemner 'Pesticide exposure in farming and forestry and the risk of uveal melanoma' indeholder.

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