TY - JOUR
T1 - Personal dialysis capacity (PDC™) test
T2 - A multicentre clinical study
AU - Van Biesen, Wim
AU - Carlsson, Ola
AU - Bergia, Roberto
AU - Brauner, Michael
AU - Christensson, Anders
AU - Genestier, Sandrine
AU - Haag-Weber, Marianne
AU - Heaf, James
AU - Joffe, Preben
AU - Johansson, Ann Cathrine
AU - Morel, Bertrand
AU - Prischl, Friedrich
AU - Verbeelen, Dirk
AU - Vychytil, Andreas
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Background. The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC™ program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens. Methods. This study evaluates the relevance of the PDC™ program when routinely used. The PDC™ data of 336 patients from nine different centres in Europe were evaluated. Results. The area parameter was 20 985 ± 7578 cm/1.73 m2 (mean±SD). The reabsorption of fluid after dissipation of glucose, JvAR, was 1.97 ± 1.00 ml/min/1.73 m2. The large pore fluid flux, JvL, was 0.11 ± 0.07 ml/min/1.73 m2. A multivariate model for prediction of serum albumin included dialysate protein loss, JvL, JvAR, nPCR, A0/ΔX, BMI and gender (R2 = 0.81, P < 0.001). Total clearance fell with increasing PD duration (P < 0.001). A negative relation between A0/ΔX and ultrafiltration (rho = -0.26, P < 0.05), a positive relation between A0/ΔX and peritoneal creatinine clearance (rho = 0.52, P < 0.05) and urea clearance (rho = 0.36, P < 0.05), and a positive relation between measured peritoneal creatinine and urea clearance (rho = 0.64, P < 0.01) was observed. Conclusions. In summary, the present study shows that the PDC™ program is a robust, accurate method to describe the peritoneal membrane transport characteristics. Analysis of PDC™ data of large groups of patients, especially if followed up over time, can give interesting information on the physiology of the peritoneal membrane and the impact of different parameters on it.
AB - Background. The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC™ program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens. Methods. This study evaluates the relevance of the PDC™ program when routinely used. The PDC™ data of 336 patients from nine different centres in Europe were evaluated. Results. The area parameter was 20 985 ± 7578 cm/1.73 m2 (mean±SD). The reabsorption of fluid after dissipation of glucose, JvAR, was 1.97 ± 1.00 ml/min/1.73 m2. The large pore fluid flux, JvL, was 0.11 ± 0.07 ml/min/1.73 m2. A multivariate model for prediction of serum albumin included dialysate protein loss, JvL, JvAR, nPCR, A0/ΔX, BMI and gender (R2 = 0.81, P < 0.001). Total clearance fell with increasing PD duration (P < 0.001). A negative relation between A0/ΔX and ultrafiltration (rho = -0.26, P < 0.05), a positive relation between A0/ΔX and peritoneal creatinine clearance (rho = 0.52, P < 0.05) and urea clearance (rho = 0.36, P < 0.05), and a positive relation between measured peritoneal creatinine and urea clearance (rho = 0.64, P < 0.01) was observed. Conclusions. In summary, the present study shows that the PDC™ program is a robust, accurate method to describe the peritoneal membrane transport characteristics. Analysis of PDC™ data of large groups of patients, especially if followed up over time, can give interesting information on the physiology of the peritoneal membrane and the impact of different parameters on it.
KW - PDC™
KW - Peritoneal dialysis
KW - PET test
KW - Renal replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=0037385328&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfg146
DO - 10.1093/ndt/gfg146
M3 - Article
C2 - 12637650
AN - SCOPUS:0037385328
SN - 0931-0509
VL - 18
SP - 788
EP - 796
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 4
ER -