Patofysiologisk forståelse og terapeutiske muligheder ved hæmning af okulær karvækst

Yousif Subhi, Lasse Jørgensen Cehofski, Anders Højslet Vestergaard, Torben Lykke Sørensen, Jakob Grauslund

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.

Bidragets oversatte titelPathological and therapeutic possibilities in inhibiting ocular angionesis
OriginalsprogDansk
ArtikelnummerV03200178
Sider (fra-til)2027-2030
Antal sider4
TidsskriftUgeskrift for Laeger
Vol/bind182
Udgave nummer21
StatusUdgivet - 26 okt. 2020

Fingeraftryk

Udforsk hvilke forskningsemner 'Patofysiologisk forståelse og terapeutiske muligheder ved hæmning af okulær karvækst' indeholder.

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