Particulate matter air pollution components and risk for lung cancer

O. Raaschou-Nielsen*, R. Beelen, M. Wang, G. Hoek, Z. J. Andersen, B. Hoffmann, M. Stafoggia, E. Samoli, G. Weinmayr, K. Dimakopoulou, M. Nieuwenhuijsen, W. W. Xun, P. Fischer, K. T. Eriksen, M. Sørensen, A. Tjønneland, F. Ricceri, K. de Hoogh, T. Key, M. EeftensP. H. Peeters, H. B. Bueno-de-Mesquita, K. Meliefste, B. Oftedal, P. E. Schwarze, P. Nafstad, C. Galassi, E. Migliore, A. Ranzi, G. Cesaroni, C. Badaloni, F. Forastiere, J. Penell, U. De Faire, M. Korek, N. Pedersen, C. G. Östenson, G. Pershagen, L. Fratiglioni, H. Concin, G. Nagel, A. Jaensch, A. Ineichen, A. Naccarati, M. Katsoulis, A. Trichpoulou, M. Keuken, A. Jedynska, I. M. Kooter, J. Kukkonen, B. Brunekreef, R. S. Sokhi, K. Katsouyanni, P. Vineis

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m3), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PM10 S (1.58; 1.03-2.44 per 200 ng/m3), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m3) and PM10 K (1.17; 1.02-1.33 per 100 ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

    Sider (fra-til)66-73
    Antal sider8
    TidsskriftEnvironment International
    StatusUdgivet - 1 feb. 2016


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