Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

Ann Olsson, Kayo Togawa, Joachim Schüz, Charlotte Le Cornet, Beatrice Fervers, Susanne Oksbjerg Dalton, Eero Pukkala, Maria Feychting, Niels Erik Skakkebæk, Johnni Hansen

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14–49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of “heavy metal(s) and solvent(s)” (OR 1.50, 95% CI 1.01–2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970–1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980–1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.

    OriginalsprogEngelsk
    Sider (fra-til)658-669
    Antal sider12
    TidsskriftScandinavian Journal of Work, Environment and Health
    Vol/bind44
    Udgave nummer6
    DOI
    StatusUdgivet - 1 jan. 2018

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)' indeholder.

    Citationsformater