Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting

Christina Ruhlmann*, Jørn Herrstedt

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    A large number of different 5-hydroxytryptamine (HT)3 receptor antagonists have been marketed with the indication of preventing nausea and vomiting induced by chemotherapy - palonosetron is the most recently developed of these. Pharmacologic studies have revealed that palonosetron has a long half-life, a high affinity for 5-HT3 receptors, exhibits allosteric binding to 5-HT3 receptors and possess positive cooperativity. Although interesting, pharmacologic differences are only useful if they result in clinical advantages, such as an increase in efficacy and/or an improvement in tolerability. We summarize preclinical and clinical studies of palonosetron and compare the efficacy and tolerability with the other 5-HT3 receptor antagonists, ondansetron, granisetron and dolasetron.

    OriginalsprogEngelsk
    Sider (fra-til)137-148
    Antal sider12
    TidsskriftExpert Review of Anticancer Therapy
    Vol/bind10
    Udgave nummer2
    DOI
    StatusUdgivet - 1 feb. 2010

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting' indeholder.

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