TY - JOUR
T1 - Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy
AU - Gehl, Julie
AU - Geertsen, Poul F.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - By short, intense electric pulses it is possible to cause cell permeabilisation (electroporation) and this can be used to deliver chemotherapy to tumours (electrochemotherapy). Preclinical studies have shown effects on vasculature of electroporation and electrochemotherapy, in particular in tumours. The effect on normal vasculature is a brief reflexory constriction; however in the fragile and abundant vasculature of tumours, a direct anti-vascular effect has been shown. This finding is mirrored in the clinical observation that bleeding, ulcerated lesions cease to bleed after application of electric pulses, and stay dry while the involution of tumours due to uptake of the cytotoxic agent takes place. Ulcerated, bleeding lesions are not uncommon in cancer patients, and cause discomfort due to bleeding and also stigmatisation when lesions are in visible areas. This report describes a case with ulcerated, bleeding lesions where the use of electrochemotherapy has led to efficient and immediate relief of symptoms.
AB - By short, intense electric pulses it is possible to cause cell permeabilisation (electroporation) and this can be used to deliver chemotherapy to tumours (electrochemotherapy). Preclinical studies have shown effects on vasculature of electroporation and electrochemotherapy, in particular in tumours. The effect on normal vasculature is a brief reflexory constriction; however in the fragile and abundant vasculature of tumours, a direct anti-vascular effect has been shown. This finding is mirrored in the clinical observation that bleeding, ulcerated lesions cease to bleed after application of electric pulses, and stay dry while the involution of tumours due to uptake of the cytotoxic agent takes place. Ulcerated, bleeding lesions are not uncommon in cancer patients, and cause discomfort due to bleeding and also stigmatisation when lesions are in visible areas. This report describes a case with ulcerated, bleeding lesions where the use of electrochemotherapy has led to efficient and immediate relief of symptoms.
KW - Bleeding lesions
KW - Cutaneous metastases
KW - Electrochemotherapy
KW - Haemorrhaging skin lesions
KW - Melanoma
UR - http://www.scopus.com/inward/record.url?scp=33750526248&partnerID=8YFLogxK
U2 - 10.1016/j.ejcsup.2006.07.007
DO - 10.1016/j.ejcsup.2006.07.007
M3 - Article
AN - SCOPUS:33750526248
VL - 4
SP - 35
EP - 37
JO - European Journal of Cancer, Supplement
JF - European Journal of Cancer, Supplement
SN - 1359-6349
IS - 11
ER -