TY - JOUR
T1 - Out-of-Hospital Cardiac Arrest related to exercise in the general population
T2 - Incidence, Survival and Bystander Response
AU - Amalie Wolthers, Signe
AU - Walther Jensen, Theo
AU - Nikolaj Blomberg, Stig
AU - Gelderman Holgersen, Mathias
AU - Lippert, Freddy
AU - Mikkelsen, Søren
AU - Mazur Hendriksen, Ole
AU - Torp-Pedersen, Christian
AU - Collatz Christensen, Helle
N1 - Copyright © 2022. Published by Elsevier B.V.
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2022/3
Y1 - 2022/3
N2 - BACKGROUND: Regular exercise is known to prevent cardiovascular disorders, but it may also trigger acute cardiac events. This study examined the incidence, prognosis, and outcomes of out-of-hospital cardiac arrest (OHCA) related to exercise in the general population of Denmark.METHODS: This retrospective cohort study examined all the OHCAs in the Danish Cardiac Arrest Registry from 2016 to 2019. OHCA related to exercise was identified in a nationwide electronic database and coupled to the patient register. Descriptive statistics were used in combination with a multivariate logistic regression model to assess predefined factors.RESULTS: A total of 20,470 OHCAs were identified, of which 459 (2.2%) were related to exercise. Most were male (75.3%), with a median age of 61 years. Further, 95% of exercise-related OHCA received bystander cardiopulmonary resuscitation, compared to 77.4% in non-exercise-related OHCA (p<0.001), and 38.3% received defibrillation by bystanders versus 7.5% in the non-exercise group (p<0.001). Exercise-related OHCAs had a 30-day survival rate of 57.7% compared to 12.6% in the non-exercise group, yielding an adjusted odds ratio of 5.56. The 30-day survival rate of exercise-related subjects aged 15-35 years was 80.0%, compared to 25.0% in the non-exercise group. When comparing sports categories, team sports were associated with the greatest chance of survival (odds ratio of 18.5 versus a non-exercise odds ratio of 0.09).CONCLUSION: Exercise-related OHCA has a low incidence and is related to a significantly better prognosis when compared to non-exercise OHCA. Furthermore, many patients experiencing exercise-related OHCA received defibrillation and cardiopulmonary resuscitation by bystanders. These findings could help plan and execute campaigns and education.
AB - BACKGROUND: Regular exercise is known to prevent cardiovascular disorders, but it may also trigger acute cardiac events. This study examined the incidence, prognosis, and outcomes of out-of-hospital cardiac arrest (OHCA) related to exercise in the general population of Denmark.METHODS: This retrospective cohort study examined all the OHCAs in the Danish Cardiac Arrest Registry from 2016 to 2019. OHCA related to exercise was identified in a nationwide electronic database and coupled to the patient register. Descriptive statistics were used in combination with a multivariate logistic regression model to assess predefined factors.RESULTS: A total of 20,470 OHCAs were identified, of which 459 (2.2%) were related to exercise. Most were male (75.3%), with a median age of 61 years. Further, 95% of exercise-related OHCA received bystander cardiopulmonary resuscitation, compared to 77.4% in non-exercise-related OHCA (p<0.001), and 38.3% received defibrillation by bystanders versus 7.5% in the non-exercise group (p<0.001). Exercise-related OHCAs had a 30-day survival rate of 57.7% compared to 12.6% in the non-exercise group, yielding an adjusted odds ratio of 5.56. The 30-day survival rate of exercise-related subjects aged 15-35 years was 80.0%, compared to 25.0% in the non-exercise group. When comparing sports categories, team sports were associated with the greatest chance of survival (odds ratio of 18.5 versus a non-exercise odds ratio of 0.09).CONCLUSION: Exercise-related OHCA has a low incidence and is related to a significantly better prognosis when compared to non-exercise OHCA. Furthermore, many patients experiencing exercise-related OHCA received defibrillation and cardiopulmonary resuscitation by bystanders. These findings could help plan and execute campaigns and education.
U2 - 10.1016/j.resuscitation.2022.01.021
DO - 10.1016/j.resuscitation.2022.01.021
M3 - Article
C2 - 35090970
SN - 0300-9572
VL - 172
SP - 84
EP - 91
JO - Resuscitation
JF - Resuscitation
ER -