Oral chemoprevention with acetyl salicylic acid, vitamin D and calcium reduces the risk of tobacco carcinogen-induced bladder tumors in mice

H. C. Pommergaard*, J. Burcharth, J. Rosenberg, H. Raskov

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Bladder cancer is a common urological malignancy with high recurrence rate, which may be reduced by chemoprevention. The aim was to evaluate chemoprevention in a mouse model of tobacco carcinogen-induced bladder tumors. A total of 60 A/J mice were randomized to normal diet, diet with low calcium, and diet with chemoprevention (acetyl salicylic acid, 1-alpha 25(0H)2-vitamin D3 and calcium). There were significantly fewer tumors (0 (0-0) vs. 0 (0-2), p = .045) and fewer animals with tumors (0/20 vs. 5/20, p = .045) in the chemoprevention group compared with controls. Thus, chemoprevention diet effectively reduced the tumor promoting effect of tobacco carcinogens in the mouse bladder.

    OriginalsprogEngelsk
    Sider (fra-til)490-493
    Antal sider4
    TidsskriftCancer Investigation
    Vol/bind31
    Udgave nummer7
    DOI
    StatusUdgivet - 1 aug. 2013

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