TY - JOUR
T1 - Optical coherence tomography imaging of psoriasis vulgaris
T2 - Correlation with histology and disease severity
AU - Morsy, Hanan
AU - Kamp, Soren
AU - Thrane, Lars
AU - Behrendt, Nille
AU - Saunder, Birgit
AU - Zayan, Hisham
AU - Elmagid, Ensaf Abd
AU - Jemec, Gregor B.E.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Epidermal thickness (ET) has been suggested as a surrogate measure of psoriasis severity. Optical coherence tomography (OCT) is a recent imaging technology that provides real-time skin images to a depth of 1.8 mm with a micrometre resolution. OCT may provide an accurate in vivo measure of ET. It is, therefore, speculated that OCT may be used in the assessment of psoriasis vulgaris. A total of 23 patients with psoriasis vulgaris were systematically evaluated by OCT imaging and skin biopsy during treatment. Biopsies were graded for disease severity, and additional evaluation was done by the physician via psoriasis area and severity index (PASI) score, and by the patient through measures such as self-administered PASI, psoriasis life stress inventory index and dermatology life quality index. ET was calculated from OCT images. In comparison to normal skin, psoriasis appeared with a more irregular surface with a stronger entrance signal, a serrated dermo-epidermal junction was found and a less signal intensity in the dermis as shown in OCT images. ET measured in untreated plaques was thicker reflecting epidermal hyperproliferation and inflammation. The changes were significantly correlated with the biopsy grading (r 2 = 0.41, p = 0.001) and ET significantly decreased with treatment (p = 0.0001). ET correlated significantly with self-reported measures of disease severity, but not with physician-assessed global PASI. The data suggest that OCT may be used to measure ET in psoriasis and the measurements correlate with several other parameters of disease severity. This implies that OCT assessment of psoriatic plaques may provide a useful method for non-invasive in vivo method to follow the evolution of psoriasis lesions.
AB - Epidermal thickness (ET) has been suggested as a surrogate measure of psoriasis severity. Optical coherence tomography (OCT) is a recent imaging technology that provides real-time skin images to a depth of 1.8 mm with a micrometre resolution. OCT may provide an accurate in vivo measure of ET. It is, therefore, speculated that OCT may be used in the assessment of psoriasis vulgaris. A total of 23 patients with psoriasis vulgaris were systematically evaluated by OCT imaging and skin biopsy during treatment. Biopsies were graded for disease severity, and additional evaluation was done by the physician via psoriasis area and severity index (PASI) score, and by the patient through measures such as self-administered PASI, psoriasis life stress inventory index and dermatology life quality index. ET was calculated from OCT images. In comparison to normal skin, psoriasis appeared with a more irregular surface with a stronger entrance signal, a serrated dermo-epidermal junction was found and a less signal intensity in the dermis as shown in OCT images. ET measured in untreated plaques was thicker reflecting epidermal hyperproliferation and inflammation. The changes were significantly correlated with the biopsy grading (r 2 = 0.41, p = 0.001) and ET significantly decreased with treatment (p = 0.0001). ET correlated significantly with self-reported measures of disease severity, but not with physician-assessed global PASI. The data suggest that OCT may be used to measure ET in psoriasis and the measurements correlate with several other parameters of disease severity. This implies that OCT assessment of psoriatic plaques may provide a useful method for non-invasive in vivo method to follow the evolution of psoriasis lesions.
KW - Disease severity
KW - Epidermal thickness
KW - Histopathology
KW - Optical coherence tomography (OCT)
KW - Psoriasis
KW - Psoriasis area and severity index (PASI)
KW - Psoriasis life stress inventory index (PLSI)
KW - Self-administered PASI (SAPASI)
UR - http://www.scopus.com/inward/record.url?scp=77449120832&partnerID=8YFLogxK
U2 - 10.1007/s00403-009-1000-4
DO - 10.1007/s00403-009-1000-4
M3 - Article
C2 - 19894055
AN - SCOPUS:77449120832
SN - 0340-3696
VL - 302
SP - 105
EP - 111
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 2
ER -