TY - JOUR
T1 - Occupational risks for uveal melanoma results from a case-control study in nine European countries
AU - Lutz, Jean Michel
AU - Cree, Ian
AU - Sabroe, Svend
AU - Kvist, Tine Kajsa
AU - Clausen, Lene Bjørk
AU - Afonso, Noemia
AU - Ahrens, Wolfgang
AU - Ballard, Terri J.
AU - Bell, Janine
AU - Cyr, Diane
AU - Eriksson, Mikael
AU - Févotte, Joëlle
AU - Guénel, Pascal
AU - Hardell, Lennart
AU - Jöckel, Karl Heinz
AU - Miranda, Ana
AU - Merletti, Franco
AU - Morales-Suarez-Varela, Maria M.
AU - Stengrevics, Aivars
AU - Lynge, Elsebeth
PY - 2005/5/1
Y1 - 2005/5/1
N2 - Objective: Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods: A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results: Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion: Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.
AB - Objective: Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods: A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results: Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion: Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.
KW - Case-control study
KW - Eye
KW - Malignant melanoma
UR - http://www.scopus.com/inward/record.url?scp=21244442007&partnerID=8YFLogxK
U2 - 10.1007/s10552-004-5029-6
DO - 10.1007/s10552-004-5029-6
M3 - Review
C2 - 15953986
AN - SCOPUS:21244442007
SN - 0957-5243
VL - 16
SP - 437
EP - 447
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 4
ER -