Occupational risks for uveal melanoma results from a case-control study in nine European countries

Jean Michel Lutz, Ian Cree, Svend Sabroe, Tine Kajsa Kvist, Lene Bjørk Clausen, Noemia Afonso, Wolfgang Ahrens, Terri J. Ballard, Janine Bell, Diane Cyr, Mikael Eriksson, Joëlle Févotte, Pascal Guénel, Lennart Hardell, Karl Heinz Jöckel, Ana Miranda, Franco Merletti, Maria M. Morales-Suarez-Varela, Aivars Stengrevics, Elsebeth Lynge*

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review


    Objective: Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods: A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results: Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion: Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.

    Sider (fra-til)437-447
    Antal sider11
    TidsskriftCancer Causes and Control
    Udgave nummer4
    StatusUdgivet - 1 maj 2005


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