TY - JOUR
T1 - Occupational risk variation of nasopharyngeal cancer in the Nordic countries
AU - Carpén, Timo
AU - Gille, Evelina
AU - Hammarstedt-Nordenvall, Lalle
AU - Hansen, Johnni
AU - Heikkinen, Sanna
AU - Lynge, Elsebeth
AU - Selander, Jenny
AU - Mehlum, Ingrid Sivesind
AU - Torfadottir, Jóhanna Eyrún
AU - Mäkitie, Antti
AU - Pukkala, Eero
N1 - © 2022. The Author(s).
PY - 2022/11/4
Y1 - 2022/11/4
N2 - BACKGROUND: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.METHODS: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961-2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference.RESULTS: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91-6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16-3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02-3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68-0.92) and male textile workers (SIR 0.49, 95% CI 0.22-0.93).CONCLUSIONS: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
AB - BACKGROUND: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.METHODS: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961-2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference.RESULTS: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91-6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16-3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02-3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68-0.92) and male textile workers (SIR 0.49, 95% CI 0.22-0.93).CONCLUSIONS: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
KW - Humans
KW - Female
KW - Male
KW - Nasopharyngeal Neoplasms/epidemiology
KW - Occupations
KW - Occupational Exposure/adverse effects
KW - Incidence
KW - Scandinavian and Nordic Countries/epidemiology
KW - Nasopharyngeal Carcinoma/epidemiology
KW - Risk Factors
KW - Occupational Diseases/epidemiology
U2 - 10.1186/s12885-022-10209-y
DO - 10.1186/s12885-022-10209-y
M3 - Article
C2 - 36333796
SN - 1471-2407
VL - 22
JO - BMC Cancer
JF - BMC Cancer
IS - 1
M1 - 1130
ER -