TY - JOUR
T1 - Obesity is a risk factor for atrial fibrillation among fertile young women
T2 - a nationwide cohort study
AU - Karasoy, Deniz
AU - Bo Jensen, Thomas
AU - Hansen, Morten Lock
AU - Schmiegelow, Michelle
AU - Lamberts, Morten
AU - Gislason, Gunnar Hilmar
AU - Hansen, Jim
AU - Torp-Pedersen, Christian
AU - Olesen, Jonas Bjerring
PY - 2013/6
Y1 - 2013/6
N2 - AIMS: Obesity has been associated with increased risk of atrial fibrillation (AF), but whether this risk is also prevalent in younger individuals is unknown. We therefore investigated the risk of AF in relation to body mass index (BMI) among young fertile women.METHODS AND RESULTS: By cross-linkage of nationwide registers of childbirth and hospitalization, we identified 271 203 women without prior AF who gave birth in Denmark between 2004 and 2009. Body mass index (kg/m(2)) was examined as a risk factor for AF using proportional hazard models. Mean age was 30.6 years (4.7 SD) and median follow-up was 4.6 years (interquartile range 2.9-5.8). During the follow-up, 110 women were hospitalized with first-time AF; very few individuals had known risk factors for AF. Overall incidence rate of AF was 9.3 [95% confidence interval (CI): 7.7-11.2] per 100 000 person-years. According to BMI, the incidence rate of AF per 100 000 person-years was 7.4 (5.6-9.7) in normal weight (BMI: 18.5-24.9), 8.5 (5.5-13.1) in overweight (BMI: 25-29.9), 15.8 (9.3-26.7) in obese (BMI: 30-35), and 27.3 (15.5-48.1) in very obese (BMI >35) individuals. Multivariable regression analyses adjusted for age, hyperthyroidism, and previous use of beta-blockers revealed a hazard ratio of 2.04 (95% CI: 1.13-3.69) in the obese and 3.50 (1.86-6.58) in the very obese individuals compared with normal weight.CONCLUSION: Obesity is a risk factor for AF among young and essentially healthy fertile women despite the low incidence of AF. These results may have implications for prevention of AF.
AB - AIMS: Obesity has been associated with increased risk of atrial fibrillation (AF), but whether this risk is also prevalent in younger individuals is unknown. We therefore investigated the risk of AF in relation to body mass index (BMI) among young fertile women.METHODS AND RESULTS: By cross-linkage of nationwide registers of childbirth and hospitalization, we identified 271 203 women without prior AF who gave birth in Denmark between 2004 and 2009. Body mass index (kg/m(2)) was examined as a risk factor for AF using proportional hazard models. Mean age was 30.6 years (4.7 SD) and median follow-up was 4.6 years (interquartile range 2.9-5.8). During the follow-up, 110 women were hospitalized with first-time AF; very few individuals had known risk factors for AF. Overall incidence rate of AF was 9.3 [95% confidence interval (CI): 7.7-11.2] per 100 000 person-years. According to BMI, the incidence rate of AF per 100 000 person-years was 7.4 (5.6-9.7) in normal weight (BMI: 18.5-24.9), 8.5 (5.5-13.1) in overweight (BMI: 25-29.9), 15.8 (9.3-26.7) in obese (BMI: 30-35), and 27.3 (15.5-48.1) in very obese (BMI >35) individuals. Multivariable regression analyses adjusted for age, hyperthyroidism, and previous use of beta-blockers revealed a hazard ratio of 2.04 (95% CI: 1.13-3.69) in the obese and 3.50 (1.86-6.58) in the very obese individuals compared with normal weight.CONCLUSION: Obesity is a risk factor for AF among young and essentially healthy fertile women despite the low incidence of AF. These results may have implications for prevention of AF.
KW - Adult
KW - Age Distribution
KW - Atrial Fibrillation/mortality
KW - Body Mass Index
KW - Causality
KW - Cohort Studies
KW - Comorbidity
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Hyperthyroidism/mortality
KW - Incidence
KW - Obesity/mortality
KW - Registries
KW - Risk Factors
KW - Women's Health/statistics & numerical data
U2 - 10.1093/europace/eus422
DO - 10.1093/europace/eus422
M3 - Article
C2 - 23284141
SN - 1099-5129
VL - 15
SP - 781
EP - 786
JO - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
IS - 6
ER -