Nye molekylære markører ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet

Thomas Stauffer Larsen; Niels Pallisgaard; Jacob Haaber Christensen; Paul Gram-Hansen; Gitte B. Kerndrup; Michael Boe Møller; Hans Carl Hasselbalch

Nye molekylære markører ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet

Thomas Stauffer Larsen^*, Niels Pallisgaard, Jacob Haaber Christensen, Paul Gram-Hansen, Gitte B. Kerndrup, Michael Boe Møller, Hans Carl Hasselbalch

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Review › Forskning › peer review

Abstract

PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.

Bidragets oversatte titel	New molecular markers within the chronic myeloproliferative disorders. I: The PRV-1 gene
Originalsprog	Dansk
Sider (fra-til)	3295-3299
Antal sider	5
Tidsskrift	Ugeskrift for laeger
Vol/bind	168
Udgave nummer	39
Status	Udgivet - 25 sep. 2006

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Citationsformater

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title = "Nye molekyl{\ae}re mark{\o}rer ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet",

abstract = "PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having {"}masked{"} PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.",

author = "Larsen, {Thomas Stauffer} and Niels Pallisgaard and Christensen, {Jacob Haaber} and Paul Gram-Hansen and Kerndrup, {Gitte B.} and M{\o}ller, {Michael Boe} and Hasselbalch, {Hans Carl}",

year = "2006",

month = sep,

day = "25",

language = "Dansk",

volume = "168",

pages = "3295--3299",

journal = "Ugeskrift for laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Nye molekylære markører ved de kroniske myeloproliferative sygdomme

T2 - I. Polycythaemia rubra vera-1-genet

AU - Larsen, Thomas Stauffer

AU - Pallisgaard, Niels

AU - Christensen, Jacob Haaber

AU - Gram-Hansen, Paul

AU - Kerndrup, Gitte B.

AU - Møller, Michael Boe

AU - Hasselbalch, Hans Carl

PY - 2006/9/25

Y1 - 2006/9/25

N2 - PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.

AB - PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.

UR - http://www.scopus.com/inward/record.url?scp=33749261593&partnerID=8YFLogxK

M3 - Review

C2 - 17032591

AN - SCOPUS:33749261593

SN - 0041-5782

VL - 168

SP - 3295

EP - 3299

JO - Ugeskrift for laeger

JF - Ugeskrift for laeger

IS - 39

ER -

Nye molekylære markører ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet

Abstract

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