Nye antidiabetiske lægemidler og kardiovaskulære komplikationer

Manan Pareek, Martin Bødtker Mortensen, Bo Løfgren, Mette Lundgren Nielsen, Michael Hecht Olsen, Niels Holmark Andersen

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstrakt

This review summarizes the cardiovascular non-inferiority trials of novel antidiabetic drugs performed since 2008, when regulatory agencies started mandating thorough examination of their cardiovascular safety. So far, eight randomized trials on three different drug classes have been completed. Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists may reduce cardiovascular risk and possibly mortality, while dipeptidyl dipeptidase-4 inhibitors may increase the risk of heart failure. A brief discussion of potential mechanisms and clinical implications is provided.

Bidragets oversatte titelNovel antidiabetic drugs and cardiovascular complications
OriginalsprogDansk
ArtikelnummerV07170551
Sider (fra-til)977-981
TidsskriftUgeskrift for laeger
Vol/bind180
Udgave nummer11
StatusUdgivet - 5 feb. 2018

Fingeraftryk Udforsk hvilke forskningsemner 'Nye antidiabetiske lægemidler og kardiovaskulære komplikationer' indeholder.

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