Nutritional supplementation and artificial reproductive technique (ART) outcomes

A. J. Kermack*, N. S. MacKlon

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewpeer review

    Abstract

    Approximately one in six couples suffer from subfertility, and many seek treatment with artificial reproductive technologies (ART). Despite improvements in laboratory techniques and ovarian stimulation, ongoing pregnancy rates per cycle remain at ∼25%. Couples wanting to improve their chances may turn to adjuvant therapies, such as nutritional supplements. There is growing evidence that periconceptional nutritional status is a key determinant of fertility and long-term health of the offspring, and a lucrative market has developed to meet the demand based on these benefits. However, the practice of routine dietary supplementation before and during IVF treatment has not been subject to well-powered prospective randomised trials. In this article, the potential roles of specific nutritional supplements in the context of improving IVF outcomes are reviewed and an assessment is made of the evidence base supporting their clinical use in this context. Finally, current research needs in the field are outlined.

    OriginalsprogEngelsk
    Sider (fra-til)677-683
    Antal sider7
    TidsskriftReproduction, Fertility and Development
    Vol/bind27
    Udgave nummer4
    DOI
    StatusUdgivet - 1 jan. 2015

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