Normal skin microbiota is altered in pre-clinical hidradenitis suppurativa

Hans Christian Ring*, Lene Bay, Klaus Kallenbach, Iben M. Miller, Errol Prens, Ditte M. Saunte, Thomas Bjarnsholt, Gregor B.E. Jemec

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginous regions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesized that clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differences were found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthy controls. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced micro-biota in patients with HS may play an important role in the early course of the disease.

OriginalsprogEngelsk
Sider (fra-til)208-213
Antal sider6
TidsskriftActa Dermato-Venereologica
Vol/bind97
Udgave nummer2
DOI
StatusUdgivet - feb. 2017

Fingeraftryk

Udforsk hvilke forskningsemner 'Normal skin microbiota is altered in pre-clinical hidradenitis suppurativa' indeholder.

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