TY - JOUR
T1 - No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study
AU - DBDS Genomic consortium group
AU - Tummoszeit, Inga Zalia
AU - Olofsson, Isa Amalie
AU - Chalmer, Mona Ameri
AU - Henriksen, Alexander Pil
AU - Aagaard, Bitten
AU - Brunak, Søren
AU - Bruun, Mie Topholm
AU - Didriksen, Maria
AU - Erikstrup, Christian
AU - Hjalgrim, Henrik
AU - Mikkelsen, Christina
AU - Mikkelsen, Susan
AU - Ostrowski, Sisse Rye
AU - Pedersen, Ole Birger Vesterager
AU - Quinn, Liam
AU - Sørensen, Erik
AU - Ullum, Henrik
AU - Olesen, Jes
AU - Banasik, Karina
AU - Hansen, Thomas Folkmann
AU - Kogelman, Lisette J A
N1 - © 2024 The Author(s). Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.
PY - 2025/1
Y1 - 2025/1
N2 - OBJECTIVE: To determine the association between human leukocyte antigen (HLA) alleles and migraine, migraine subtypes, and sex-specific factors.BACKGROUND: It has long been hypothesized that inflammation contributes to migraine pathophysiology. This study examined the association between migraine and alleles in the HLA system, a key player in immune response and genetic diversity.METHODS: We performed a case-control study and included 13,210 individuals with migraine and 86,738 controls. All participants were part of the Danish Blood Donor Study Genomic Cohort. Participants were genotyped and 111 HLA alleles on 15 HLA genes were imputed. We examined the association between HLA alleles and migraine subtypes, considering sex-specific differences.RESULTS: We found no association between HLA alleles and migraine, neither overall, nor in the sex-specific analysis. In the migraine subtype analysis, three HLA alleles were associated with migraine without aura; however, these associations could not be replicated in an independent Icelandic cohort (2191 individuals with migraine without aura and 278,858 controls). Furthermore, we found no association between HLA alleles and migraine with aura or chronic migraine.CONCLUSION: We found no evidence of an association between the HLA system and migraine, suggesting that genetic factors related to the HLA system do not play a significant role in migraine susceptibility.
AB - OBJECTIVE: To determine the association between human leukocyte antigen (HLA) alleles and migraine, migraine subtypes, and sex-specific factors.BACKGROUND: It has long been hypothesized that inflammation contributes to migraine pathophysiology. This study examined the association between migraine and alleles in the HLA system, a key player in immune response and genetic diversity.METHODS: We performed a case-control study and included 13,210 individuals with migraine and 86,738 controls. All participants were part of the Danish Blood Donor Study Genomic Cohort. Participants were genotyped and 111 HLA alleles on 15 HLA genes were imputed. We examined the association between HLA alleles and migraine subtypes, considering sex-specific differences.RESULTS: We found no association between HLA alleles and migraine, neither overall, nor in the sex-specific analysis. In the migraine subtype analysis, three HLA alleles were associated with migraine without aura; however, these associations could not be replicated in an independent Icelandic cohort (2191 individuals with migraine without aura and 278,858 controls). Furthermore, we found no association between HLA alleles and migraine with aura or chronic migraine.CONCLUSION: We found no evidence of an association between the HLA system and migraine, suggesting that genetic factors related to the HLA system do not play a significant role in migraine susceptibility.
KW - Adult
KW - Alleles
KW - Blood Donors/statistics & numerical data
KW - Case-Control Studies
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Genetic Predisposition to Disease
KW - HLA Antigens/genetics
KW - Humans
KW - Iceland/epidemiology
KW - Male
KW - Middle Aged
KW - Migraine Disorders/genetics
U2 - 10.1111/head.14784
DO - 10.1111/head.14784
M3 - Article
C2 - 39352055
SN - 0017-8748
VL - 65
SP - 124
EP - 131
JO - Headache
JF - Headache
IS - 1
ER -