New insights into mechanisms behind miscarriage

Elisabeth Clare Larsen, Ole Bjarne Christiansen, Astrid Marie Kolte, Nick Macklon

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    Abstrakt

    Sporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is considered a distinct disease entity. Sporadic miscarriages are considered to primarily represent failure of abnormal embryos to progress to viability. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and various endocrine disturbances. However, none of these conditions is specific to recurrent miscarriage or always associated with repeated early pregnancy loss. In recent years, new theories about the mechanisms behind sporadic and recurrent miscarriage have emerged. Epidemiological and genetic studies suggest a multifactorial background where immunological dysregulation in pregnancy may play a role, as well as lifestyle factors and changes in sperm DNA integrity. Recent experimental evidence has led to the concept that the decidualized endometrium acts as biosensor of embryo quality, which if disrupted, may lead to implantation of embryos destined to miscarry. These new insights into the mechanisms behind miscarriage offer the prospect of novel effective interventions that may prevent this distressing condition.

    OriginalsprogEngelsk
    Artikelnummer154
    TidsskriftBMC Medicine
    Vol/bind11
    Udgave nummer1
    DOI
    StatusUdgivet - 26 jun. 2013

    Fingeraftryk Udforsk hvilke forskningsemner 'New insights into mechanisms behind miscarriage' indeholder.

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