Nausea and vomiting

Pernille H. Hansen, Jesper Palshof, Jørn Herrstedt*

*Corresponding author af dette arbejde

    Publikation: Bidrag til bog/antologi/rapportKapitelForskningpeer review

    Abstract

    Despite the fact that research in the mechanism of vomiting goes back more than 300 years, there are still major gaps in our knowledge. The first report of the clinical use of an antineoplastic drug was published in 1942, but it was not until cisplatin, the most emetogenic of all drugs, was approved in 1978, the necessity of focusing on antiemetic research became evident. This chapter will focus on the biological basis of nausea and vomiting from the time of the very simple animal experiments, suggesting the existence of a vomiting center, to current research methodology enabling precise subdivision of receptors involved in the emetic reflex arch.

    OriginalsprogEngelsk
    TitelPathobiology of Cancer Regimen-Related Toxicities
    ForlagSpringer New York
    Sider99-119
    Antal sider21
    ISBN (Elektronisk)9781461454380
    ISBN (Trykt)9781461454373
    DOI
    StatusUdgivet - 1 jan. 2013

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