Natural history of recurrent pleomorphic adenoma: implications on management

Matthijs H Valstar, Simon Andreasen, Patrick A Bhairosing, Mark McGurk

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: Treating recurrent pleomorphic adenoma (RPA) aims to reduce risk of malignant transformation (MT) while avoiding facial nerve injury. Our objective was to systematically investigate this natural history of RPA and address the current rational for its treatment.

METHODS: The follow-up data of two nationwide series of PA was pooled with a focus on risk of MT and analyzed against the literature.

RESULTS: The combined nationwide data (n = 9003 PA patients) showed 3.1% with first recurrence of which 6.2% were malignant. In the literature first RPA rate was >7% at 20 years follow-up. MT occurred in 0% to 7%, and facial nerve damage increased from with each surgery 3% to 16% at first RPA to 18% to 30% at second RPA.

CONCLUSIONS: RPA showed a characteristic course with surgery being unreliable and damage to the facial nerve. The risk of MT was low. This might give flexibility towards a more conservative approach of management.

Sider (fra-til)2058-2066
Antal sider9
TidsskriftHead and Neck
Udgave nummer8
Tidlig onlinedato18 mar. 2020
StatusUdgivet - aug. 2020

Bibliografisk note

© 2020 Wiley Periodicals, Inc.


Udforsk hvilke forskningsemner 'Natural history of recurrent pleomorphic adenoma: implications on management' indeholder.