Myocardial Na,K-ATPase and digoxin therapy in human heart failure

Keld Kjeldsen; Henning Bundgaard

doi:10.1111/j.1749-6632.2003.tb07285.x

Myocardial Na,K-ATPase and digoxin therapy in human heart failure

Keld Kjeldsen^*, Henning Bundgaard

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

Originalsprog	Engelsk
Sider (fra-til)	702-707
Antal sider	6
Tidsskrift	Annals of the New York Academy of Sciences
Vol/bind	986
DOI	https://doi.org/10.1111/j.1749-6632.2003.tb07285.x
Status	Udgivet - 1 jan. 2003

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keywords = "Digoxin, Heart failure, Na,K-ATPase",

author = "Keld Kjeldsen and Henning Bundgaard",

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AU - Bundgaard, Henning

PY - 2003/1/1

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N2 - The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

AB - The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.

KW - Digoxin

KW - Heart failure

KW - Na,K-ATPase

UR - http://www.scopus.com/inward/record.url?scp=0037564210&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2003.tb07285.x

DO - 10.1111/j.1749-6632.2003.tb07285.x

M3 - Article

C2 - 12763921

AN - SCOPUS:0037564210

VL - 986

SP - 702

EP - 707

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -

Myocardial Na,K-ATPase and digoxin therapy in human heart failure

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