Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben L. Sorensen; Corinna Trebst; Pia Kivisäkk; Karen L. Klaege; Amit Majmudar; Rivka Ravid; Hans Lassmann; David B. Olsen; Robert M. Strieter; Richard M. Ransohoff; Finn Sellebjerg

doi:10.1016/S0165-5728(02)00097-8

Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben L. Sorensen^*, Corinna Trebst, Pia Kivisäkk, Karen L. Klaege, Amit Majmudar, Rivka Ravid, Hans Lassmann, David B. Olsen, Robert M. Strieter, Richard M. Ransohoff, Finn Sellebjerg

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-γ-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

Originalsprog	Engelsk
Sider (fra-til)	59-68
Antal sider	10
Tidsskrift	Journal of Neuroimmunology
Vol/bind	127
Udgave nummer	1-2
DOI	https://doi.org/10.1016/S0165-5728(02)00097-8
Status	Udgivet - 18 jun. 2002

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@article{a00c936be3aa4cb3b0048087c9bceda0,

title = "Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system",

abstract = "T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-γ-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.",

keywords = "Central nervous system, CXCL10, CXCR3, Demyelination, Inflammation, Multiple sclerosis",

author = "Sorensen, {Torben L.} and Corinna Trebst and Pia Kivis{\"a}kk and Klaege, {Karen L.} and Amit Majmudar and Rivka Ravid and Hans Lassmann and Olsen, {David B.} and Strieter, {Robert M.} and Ransohoff, {Richard M.} and Finn Sellebjerg",

year = "2002",

month = jun,

day = "18",

doi = "10.1016/S0165-5728(02)00097-8",

language = "English",

volume = "127",

pages = "59--68",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Multiple sclerosis

T2 - A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

AU - Sorensen, Torben L.

AU - Trebst, Corinna

AU - Kivisäkk, Pia

AU - Klaege, Karen L.

AU - Majmudar, Amit

AU - Ravid, Rivka

AU - Lassmann, Hans

AU - Olsen, David B.

AU - Strieter, Robert M.

AU - Ransohoff, Richard M.

AU - Sellebjerg, Finn

PY - 2002/6/18

Y1 - 2002/6/18

N2 - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-γ-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

AB - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-γ-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

KW - Central nervous system

KW - CXCL10

KW - CXCR3

KW - Demyelination

KW - Inflammation

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0036275625&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(02)00097-8

DO - 10.1016/S0165-5728(02)00097-8

M3 - Article

C2 - 12044976

AN - SCOPUS:0036275625

SN - 0165-5728

VL - 127

SP - 59

EP - 68

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Abstract

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