Mortality rates in patients with chronic hepatitis c and cirrhosis compared with the general population: A danish cohort study

Sofie Hallager*, Peer Brehm Christensen, Steen Ladelund, Mette Rye Clausen, Alex Lund Laursen, Axel Møller, Poul Schlicthting, Lone Galmstrup Madsen, Jan Gerstoft, Suzanne Lunding, Karin Elmegaard Grønbæk, Henrik Bygum Krarup, Nina Weis

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Background. Knowledge about mortality rates (MRS) in patients with chronic hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause MRS among patients with CHC with or without cirrhosis in Denmark compared with the general population. Methods. Patients registered in the Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was assessed by means of liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex-and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries. Results. A total of 3410 patients with CHC (1014 with cirrhosis), and 67 315 matched individuals were included. Adjusted MR ratios (MRRs) between patients with or without cirrhosis and their comparison cohorts were 5.64 (95% confidence interval [CI], 4.76-6.67) and 1.94 (1.55-2.42), respectively. Cirrhosis among patients was associated with an MRR of 4.03 (95% CI, 3.43-4.72). A cure for CHC was associated with an MRR of 0.64 (95% CI, 0.40-1.01) among cirrhotic patients and 2.33 (1.47-3.67) compared with the general population. Conclusions. MRS were high among patients with CHC with or without cirrhosis compared with the general population. Curing CHC was associated with a reduction in MR among cirrhotic patients, but the MR remained higher than the general population.

OriginalsprogEngelsk
Sider (fra-til)192-201
Antal sider10
TidsskriftJournal of Infectious Diseases
Vol/bind215
Udgave nummer2
DOI
StatusUdgivet - 15 jan. 2017

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