Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

Irving Nachamkin, Jørgen Engberg, Michaela Gutacker, Richard J. Meinersman, Chun Yan Li, Patricia Arzate, Erin Teeple, Vivian Fussing, Tony W. Ho, Arthur K. Asbury, John W. Griffin, Guy M. McKhann, Jean Claude Piffaretti

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    Abstrakt

    Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.

    OriginalsprogEngelsk
    Sider (fra-til)221-226
    Antal sider6
    TidsskriftJournal of Infectious Diseases
    Vol/bind184
    Udgave nummer2
    DOI
    StatusUdgivet - 15 jul. 2001

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis' indeholder.

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