Molecular aspects of implantation failure

Y. E.M. Koot*, G. Teklenburg, M. S. Salker, J. J. Brosens, N. S. Macklon

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewpeer review

    Abstrakt

    Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly understood. However, insights gained from clinical implantation failure, early pregnancy loss, and emerging techologies that enable molecular interrogation of endometrial-embryo interactions are unravelling this major limiting step in human reproduction. We review current molecular concepts thought to underlie implantation failure, consider the contribution of embryonic and endometrial factors, and discuss the clinical value of putative markers of impaired endometrial receptivity. Finally we highlight the nature of the dialogue between the maternal endometrium and the implanting embryo and discuss the concept of natural embryo selection. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure.

    OriginalsprogEngelsk
    Sider (fra-til)1943-1950
    Antal sider8
    TidsskriftBiochimica et Biophysica Acta - Molecular Basis of Disease
    Vol/bind1822
    Udgave nummer12
    DOI
    StatusUdgivet - 1 dec. 2012

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Molecular aspects of implantation failure' indeholder.

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