TY - JOUR
T1 - Molecular aspects of implantation failure
AU - Koot, Y. E.M.
AU - Teklenburg, G.
AU - Salker, M. S.
AU - Brosens, J. J.
AU - Macklon, N. S.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly understood. However, insights gained from clinical implantation failure, early pregnancy loss, and emerging techologies that enable molecular interrogation of endometrial-embryo interactions are unravelling this major limiting step in human reproduction. We review current molecular concepts thought to underlie implantation failure, consider the contribution of embryonic and endometrial factors, and discuss the clinical value of putative markers of impaired endometrial receptivity. Finally we highlight the nature of the dialogue between the maternal endometrium and the implanting embryo and discuss the concept of natural embryo selection. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure.
AB - Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly understood. However, insights gained from clinical implantation failure, early pregnancy loss, and emerging techologies that enable molecular interrogation of endometrial-embryo interactions are unravelling this major limiting step in human reproduction. We review current molecular concepts thought to underlie implantation failure, consider the contribution of embryonic and endometrial factors, and discuss the clinical value of putative markers of impaired endometrial receptivity. Finally we highlight the nature of the dialogue between the maternal endometrium and the implanting embryo and discuss the concept of natural embryo selection. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure.
KW - Embryo
KW - Endometrium
KW - Implantation failure
KW - IVF
KW - Receptivity
UR - http://www.scopus.com/inward/record.url?scp=84868475700&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2012.05.017
DO - 10.1016/j.bbadis.2012.05.017
M3 - Review
C2 - 22683339
AN - SCOPUS:84868475700
SN - 0925-4439
VL - 1822
SP - 1943
EP - 1950
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 12
ER -