Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

Kristian S Frederiksen, Karine Madsen, Birgitte B Andersen, Nina Beyer, Ellen Garde, Peter Høgh, Gunhild Waldemar, Steen G Hasselbalch, Ian Law

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease.

Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs).

Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness.

Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

OriginalsprogEngelsk
Sider (fra-til)208-215
Antal sider8
TidsskriftAlzheimer's and Dementia: Translational Research and Clinical Interventions
Vol/bind5
DOI
StatusUdgivet - 2019

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