Mitochondria-A target for attenuation of astrocyte pathology

Marlene Thorsen Morch, Reza Khorooshi, Joanna Marczynska, Magdalena Dubik, Soeren Nielsen, John Dirk Nieland, Nasrin Asgari, Trevor Owens

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.

OriginalsprogEngelsk
Sider (fra-til)577657
TidsskriftJournal of Neuroimmunology
Vol/bind358
Tidlig onlinedato14 jul. 2021
DOI
StatusUdgivet - 15 sep. 2021

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Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

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