Mikroalbuminuri som prædiktor af aterosklerotisk kardiovaskulær sygdom ved IDDM

Torsten Deckert*, Hiroki Yokoyama, Elisabeth R. Mathiesen, Birgitte Rønn, Tonny J. Jensen, Bo F. Feldt-Rasmussen, Knut Borch-Johnsen, Jan Skov Jensen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    The aim of this follow-up study was to assess whether slightly elevated urinary albumin excretion, i.e., microalbuminuria, precedes development of atherosclerotic vascular disease in IDDM. Out of 259 IDDM-patients 30 developed vascular disease during 2,457 person-years. Microalbuminuria was significantly predictive of vascu-lar disease (hazard ratio (95% confidence interval) 1.06 (1.02-1.18) per 5 mg/24 hours increase in urinary albumin excretion; p=0.002). The predictive effect was independent of age, sex, blood pressure, tobacco smoking, serum concentrations of total-cholesterol, HDL-cholesterol, sialic acid, and von Willebrand factor, and of haemoglobin A 1c, insulin dose, diabetes duration, and diabetic nephropathy (hazard ratio (95% confidence interval) 1.04 (1.01-1.08) per 5 mg/24 hours increase in urinary albumin excretion; p=0.03). It is concluded that slightly elevated urinary albumin excretion is an independent predictor of atherosclerotic vascular disease in insulin-dependent diabetes mellitus.

    Bidragets oversatte titelMicroalbuminuria as predictor of atherosclerotic vascular disease in IDDM
    OriginalsprogDansk
    Sider (fra-til)3010-3014
    Antal sider5
    TidsskriftUgeskrift for laeger
    Vol/bind159
    Udgave nummer20
    StatusUdgivet - 1 dec. 1997

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