Maintenance of high-energy brain phosphorous compounds during insulin-induced hypoglycemia in men. 31P nuclear magnetic resonance spectroscopy study

J. Hilsted, K. E. Jensen, C. Thomsen, S. Larsen, O. Henriksen

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    Abstrakt

    31P nuclear magnetic resonance (NMR) spectroscopy allows noninvasive studies of cerebral energy-rich phosphorous compounds in humans. In an attempt to characterize the relationship between peripheral blood glucose concentrations and whole-brain phosphate metabolism during insulin-induced hypoglycemia, 31P NMR spectra were obtained before and after intravenous injection of insulin (0.15 IU/kg body wt) in six men. Compared with prehypoglycemic measurements, no significant changes were found in brain content of P(i), sugar phosphates, phosphocreatine, phosphodiesters, and ATP, and brain pH remained constant during the experiment. These results show that the integrated brain profile of energy-rich phosphorous compounds is unaffected by experimental insulin-induced hypoglycemia in humans.

    OriginalsprogEngelsk
    Sider (fra-til)760-762
    Antal sider3
    TidsskriftDiabetes
    Vol/bind37
    Udgave nummer6
    DOI
    StatusUdgivet - 1 jan. 1988

    Fingeraftryk Udforsk hvilke forskningsemner 'Maintenance of high-energy brain phosphorous compounds during insulin-induced hypoglycemia in men. <sup>31</sup>P nuclear magnetic resonance spectroscopy study' indeholder.

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