Magnetic resonance imaging of the bone marrow in patients with acute leukemia during and after chemotherapy: Changes in t1 relaxation

K. E. Jensen*, P. Grundtvig Sørensen, C. Thomsen, P. Christoffersen, O. Henriksen, H. Karle

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Twenty-seven patients with acute leukemia were examined at the time of diagnosis with MR imaging and in vivo T1 relaxation time measurements of the hemopoietic bone marrow. A 1.5 T whole body magnetic resonance scanner was used. Twenty of the patients had follow-up examinations in relation to chemotherapy. Bone marrow biopsies from the posterior iliac crest were obtained within a short time interval of all MR examinations. at the time of diagnosis, T1 relaxation times were increased significantly in all the leukemic patients, compared with 24 age-matched controls. A decrease in T1 relaxation time towards or into the normal range was observed in 10 patients who obtained remission. the T1 relaxation time remained prolonged in 6 patients who failed to obtain remission during chemotherapy. Four patients, who obtained remission with concomitant decrease of T1 values towards or into the normal range, also showed prolongation of T1 relaxation time in relation to leukemic relapse. the results indicate that changes observed in T1 relaxation times of the hemopoietic bone marrow in patients with acute leukemia reflect changes in disease activity, and, that serial measurements of T1 values may provide clinically useful information with the possibility for identification of residual disease in regions inaccessible for biopsy

    OriginalsprogEngelsk
    Sider (fra-til)361-369
    Antal sider9
    TidsskriftActa Radiologica
    Vol/bind31
    Udgave nummer4
    DOI
    StatusUdgivet - 1 jan. 1990

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Magnetic resonance imaging of the bone marrow in patients with acute leukemia during and after chemotherapy: Changes in t1 relaxation' indeholder.

    Citationsformater