Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials

Daniel Glinatsi*, Joshua F. Baker, Merete L. Hetland, Kim Hørslev-Petersen, Bo J. Ejbjerg, Kristian Stengaard-Pedersen, Peter Junker, Torkell Ellingsen, Hanne M. Lindegaard, Hansen, Tine Lottenburger, Jakob M. Møller, Lykke Ørnbjerg, Aage Vestergaard, Anne Grethe Jurik, Henrik S. Thomsen, Trine Torfing, Signe Møller-Bisgaard, Mette B. Axelsen, Mikkel Østergaard

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Objectives T o examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PRO s). Methods Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTR A/OP ERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. Results MRI inflammation, but not damage, showed statistically significant associations with HAQ, VASPtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PRO s, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patientreported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PRO s. Conclusions MRI-assessed inflammation, but not damage, in early RA wrists is associated with patientreported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand.

OriginalsprogEngelsk
Sider (fra-til)1707-1715
Antal sider9
TidsskriftAnnals of the Rheumatic Diseases
Vol/bind76
Udgave nummer10
DOI
StatusUdgivet - okt. 2017

Fingeraftryk

Udforsk hvilke forskningsemner 'Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials' indeholder.

Citationsformater