Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

Hans Rasmussen, Vibe G Frokjaer*, Rikke W Hilker, Jacob Madsen, Simon Anhøj, Bob Oranje, Lars H Pinborg, Birte Glenthøj, Gitte M Knudsen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.

OriginalsprogEngelsk
Sider (fra-til)1248-50
Antal sider3
TidsskriftEuropean Neuropsychopharmacology
Vol/bind26
Udgave nummer7
DOI
StatusUdgivet - jul. 2016
Udgivet eksterntJa

Bibliografisk note

Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

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