Low and high body mass index in hidradenitis suppurativa patients—different subtypes?

P. Theut Riis*, D. M. Saunte, F. Benhadou, V. del Marmol, P. Guillem, M. El-Domyati, H. Abdel-Wahab, C. Antoniou, C. Dessinioti, M. A. Gürer, B. Beksaç, J. C. Szepietowski, L. Matusiak, L. Emtestam, J. Lapins, H. Riad, N. Doss, A. F. Massa, I. Hamzavi, C. NicholsonM. Dolenc-Voljc, K. H. Kim, J. Ohn, C. C. Zouboulis, I. Karagiannidis, Z. B. Mokos, P. Durinec, G. B.E. Jemec

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.

OriginalsprogEngelsk
Sider (fra-til)307-312
Antal sider6
TidsskriftJournal of the European Academy of Dermatology and Venereology
Vol/bind32
Udgave nummer2
DOI
StatusUdgivet - 1 feb. 2018

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