TY - JOUR
T1 - Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients
AU - Gradel, Kim Oren
AU - Póvoa, Pedro
AU - Garvik, Olav Sivertsen
AU - Vinholt, Pernille Just
AU - Nielsen, Stig Lønberg
AU - Jensen, Thøger Gorm
AU - Chen, Ming
AU - Dessau, Ram Benny
AU - Møller, Jens Kjølseth
AU - Coia, John Eugenio
AU - Ljungdalh, Pernille Sanberg
AU - Lassen, Annmarie Touborg
AU - Frederiksen, Henrik
PY - 2020/3/24
Y1 - 2020/3/24
N2 - BACKGROUND: No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).METHODS: We studied defined events in 818 adult patients with AML in relation to 60,209 CRP and PA measures. We investigated correlations between CRP and PA levels and daily CRP and PA levels in relation to AML diagnosis, AML relapse, or bacteraemia (all ±30 days), and death (─30-0 days).RESULTS: On the AML diagnosis date (D0), CRP levels increased with higher WHO performance score (PS), e.g. patients with PS 3/4 had 68.1 mg/L higher CRP compared to patients with PS 0, adjusted for relevant covariates. On D0, the PA level declined with increasing PS, e.g. PS 3/4 had 7.54 g/L lower adjusted PA compared to PS 0. CRP and PA levels were inversely correlated for the PA interval 25-55 g/L (R = - 0.51, p < 10-5), but not for ≤24 g/L (R = 0.01, p = 0.57). CRP increases and PA decreases were seen prior to bacteraemia and death, whereas no changes occurred up to AML diagnosis or relapse. CRP increases and PA decreases were also found frequently in individuals, unrelated to a pre-specified event.CONCLUSIONS: PA decrease is an important biomarker for imminent bacteraemia in adult patients with AML.
AB - BACKGROUND: No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).METHODS: We studied defined events in 818 adult patients with AML in relation to 60,209 CRP and PA measures. We investigated correlations between CRP and PA levels and daily CRP and PA levels in relation to AML diagnosis, AML relapse, or bacteraemia (all ±30 days), and death (─30-0 days).RESULTS: On the AML diagnosis date (D0), CRP levels increased with higher WHO performance score (PS), e.g. patients with PS 3/4 had 68.1 mg/L higher CRP compared to patients with PS 0, adjusted for relevant covariates. On D0, the PA level declined with increasing PS, e.g. PS 3/4 had 7.54 g/L lower adjusted PA compared to PS 0. CRP and PA levels were inversely correlated for the PA interval 25-55 g/L (R = - 0.51, p < 10-5), but not for ≤24 g/L (R = 0.01, p = 0.57). CRP increases and PA decreases were seen prior to bacteraemia and death, whereas no changes occurred up to AML diagnosis or relapse. CRP increases and PA decreases were also found frequently in individuals, unrelated to a pre-specified event.CONCLUSIONS: PA decrease is an important biomarker for imminent bacteraemia in adult patients with AML.
U2 - 10.1186/s12885-020-06754-z
DO - 10.1186/s12885-020-06754-z
M3 - Article
C2 - 32209087
SN - 1471-2407
VL - 20
SP - 249
JO - BMC Cancer
JF - BMC Cancer
IS - 1
ER -