Long-term exposure to traffic-related air pollution and diabetes-associated mortality: A cohort study

O. Raaschou-Nielsen, M. Sørensen, M. Ketzel, O. Hertel, S. Loft, A. Tjønneland, K. Overvad, Z. J. Andersen

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Aims/hypothesis: The aim of this study was to investigate whether air pollution from traffic at a residence is associated with mortality related to type 1 or type 2 diabetes. Methods: We followed up 52,061 participants in the Danish Diet, Cancer and Health cohort for diabetes-related mortality in the nationwide Register of Causes of Death, from baseline in 1993-1997 up to the end of 2009, and traced their residential addresses since 1971 in the Central Population Registry. We used dispersion-modelled concentration of nitrogen dioxide (NO2) since 1971 and amount of traffic at the baseline residence as indicators of traffic-related air pollution and used Cox regression models to estimate mortality-rate ratios (MRRs) with adjustment for potential confounders. Results: Mean levels of NO2 at the residence since 1971 were significantly associated with mortality from diabetes. Exposure above 19.4 μg/m3 (upper quartile) was associated with a MRR of 2.15 (95% CI 1.21, 3.83) when compared with below 13.6 μg/m3 (lower quartile), corresponding to an MRR of 1.31 (95% CI 0.98, 1.76) per 10 μg/m3 NO2 after adjustment for potential confounders. Conclusions/ interpretation: This study suggests that traffic-related air pollution is associated with mortality from diabetes. If confirmed, reduction in population exposure to traffic-related air pollution could be an additional strategy against the global public health burden of diabetes.

    OriginalsprogEngelsk
    Sider (fra-til)36-46
    Antal sider11
    TidsskriftDiabetologia
    Vol/bind56
    Udgave nummer1
    DOI
    StatusUdgivet - 1 jan. 2013

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