Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

Kathrin Wolf, Massimo Stafoggia, Giulia Cesaroni, Zorana Jovanovic Andersen, Rob Beelen, Claudia Galassi, Frauke Hennig, Enrica Migliore, Johanna Penell, Fulvio Ricceri, Mette Sørensen, Anu W. Turunen, Regina Hampel, Barbara Hoffmann, Hagen Kälsch, Tiina Laatikainen, Göran Pershagen, Ole Raaschou-Nielsen, Carlotta Sacerdote, Paolo VineisChiara Badaloni, Josef Cyrys, Kees De Hoogh, Kirsten T. Eriksen, Aleksandra Jedynska, Menno Keuken, Ingeborg Kooter, Timo Lanki, Andrea Ranzi, Dorothea Sugiri, Ming Yi Tsai, Meng Wang, Gerard Hoek, Bert Brunekreef, Annette Peters, Francesco Forastiere

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Background: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events. Methods: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results. Results: A 100 ng/m increase in PM10 K and a 50 ng/m increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K. Conclusions: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.

    OriginalsprogEngelsk
    Sider (fra-til)565-574
    Antal sider10
    TidsskriftEpidemiology
    Vol/bind26
    Udgave nummer4
    DOI
    StatusUdgivet - 4 jul. 2015

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