TY - JOUR
T1 - Long-term exposure to fine particulate matter and breast cancer incidence in the danish nurse cohort study
AU - Andersen, Zorana Jovanovic
AU - Ravnskjer, Line
AU - Andersen, Klaus Kaae
AU - Loft, Steffen
AU - Brandt, Jørgen
AU - Becker, Thomas
AU - Ketzel, Matthias
AU - Hertel, Ole
AU - Lynge, Elsebeth
AU - Brauner, Elvira Vaclavik
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background: An association between air pollution and breast cancer risk has been suggested, but evidence is sparse and inconclusive. Methods: We included 22,877 female nurses from the Danish Nurse Cohort who were recruited in 1993 or 1999 and followed them for incidence of breast cancer (N = 1,145) until 2013 in the Danish Cancer Register. We estimated annual mean concentrations of particulate matter with diameter <2.5 mg/m3 (PM2.5) and <10 mg/m3 (PM10), and nitrogen dioxide (NO2) at nurses' residences since 1990 using an atmospheric chemistry transport model. We examined the association between the 3-year running mean of each pollutant and breast cancer incidence using a time-varying Cox regression. Results: We found no association between breast cancer and PM2.5 (HR, 0.99; 95% confidence interval, 0.94-1.10 per interquartilerangeof3.3mg/m3),PM10(1.02;0.94-1.10per2.9mg/m3), or NO2 (0.99; 0.93-1.05 per 7.4 mg/m3). Conclusions: Air pollution is not associated with breast cancer risk. Impact: Exposure to air pollution in adulthood does not increase the risk of breast cancer, but more data on the effects of early exposure, before first birth, are needed.
AB - Background: An association between air pollution and breast cancer risk has been suggested, but evidence is sparse and inconclusive. Methods: We included 22,877 female nurses from the Danish Nurse Cohort who were recruited in 1993 or 1999 and followed them for incidence of breast cancer (N = 1,145) until 2013 in the Danish Cancer Register. We estimated annual mean concentrations of particulate matter with diameter <2.5 mg/m3 (PM2.5) and <10 mg/m3 (PM10), and nitrogen dioxide (NO2) at nurses' residences since 1990 using an atmospheric chemistry transport model. We examined the association between the 3-year running mean of each pollutant and breast cancer incidence using a time-varying Cox regression. Results: We found no association between breast cancer and PM2.5 (HR, 0.99; 95% confidence interval, 0.94-1.10 per interquartilerangeof3.3mg/m3),PM10(1.02;0.94-1.10per2.9mg/m3), or NO2 (0.99; 0.93-1.05 per 7.4 mg/m3). Conclusions: Air pollution is not associated with breast cancer risk. Impact: Exposure to air pollution in adulthood does not increase the risk of breast cancer, but more data on the effects of early exposure, before first birth, are needed.
UR - http://www.scopus.com/inward/record.url?scp=85014535525&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-16-0578
DO - 10.1158/1055-9965.EPI-16-0578
M3 - Article
C2 - 27913396
AN - SCOPUS:85014535525
SN - 1055-9965
VL - 26
SP - 428
EP - 430
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 3
ER -