Long-term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT-ICU trial - protocol and statistical analysis plan

Elena Crescioli*, Jens Østergaard Riis, Ulla Møller Weinreich, Jens Ulrik Staehr Jensen, Lone Musaeus Poulsen, Anne Craveiro Brøchner, Theis Lange, Anders Perner, Thomas Lass Klitgaard, Olav Lilleholt Schjørring, Bodil Steen Rasmussen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftProtokolForskningpeer review

Abstract

BACKGROUND: Although supplemental oxygen can be lifesaving, liberal oxygen administration causing hyperoxaemia may be harmful. The targets for oxygenation in patients with acute hypoxaemic respiratory failure acutely admitted to the intensive care unit (ICU) are strongly debated, and consensus on which targets to recommend has not been reached. The Handling Oxygenation Targets in the ICU (HOT-ICU) trial is a multicentre, randomised, parallel-group trial of a lower oxygenation target (arterial partial pressure of oxygen [PaO 2 ] = 8 kPa) versus a higher oxygenation target (PaO 2 = 12 kPa) in adult ICU patients with acute hypoxaemic respiratory failure. In this study, we aim to evaluate the effects of these targets on long-term cognitive and pulmonary function in Danish patients, enrolled in the HOT-ICU trial and surviving to 1-year follow-up. We hypothesise that a lower oxygenation target throughout the ICU stay may result in cognitive impairment, whereas a higher oxygenation target may result in impaired pulmonary function.

METHODS: All patients enrolled in the HOT-ICU trial at Danish sites and surviving to 1 year after randomisation are eligible to participate. The last patient is expected to be included by November 2021. A Repeatable Battery for the Assessment of Neuropsychological Status and a body plethysmography, including diffusion capacity for carbon monoxide, both pre-planned secondary long-term outcomes of the HOT-ICU trial, will be obtained.

CONCLUSION: This study will provide important information on the long-term effects of a lower versus a higher oxygenation target on cognitive and pulmonary function in adult ICU patients with acute hypoxaemic respiratory failure.

OriginalsprogEngelsk
Sider (fra-til)282-287
Antal sider6
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind66
Udgave nummer2
Tidlig onlinedato8 nov. 2021
DOI
StatusUdgivet - feb. 2022

Bibliografisk note

© 2021 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Fingeraftryk

Udforsk hvilke forskningsemner 'Long-term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT-ICU trial - protocol and statistical analysis plan' indeholder.

Citationsformater